Salmonella tphimurium DT104

31st October, 2022 Health

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Context

Recent studies have found the emergence of multi-drug resistant Salmonella tphimurium DT104 that causes infections in humans and cattle.

Background

The rapid and unselective use of traditional antibiotics gives rise to the emergence of drug resistant variants in Salmonella serovars. This has increased the difficulties in curing Salmonella-induced food-borne illnesses (majorly typhoid or paratyphoid fever, gastroenteritis, and diarrhoea) worldwide.
Salmonella typhimurium ST313, an invasive non-typhoidal Salmonella serovar, causes bloodstream infection in the malnourished and immunocompromised population of sub-Saharan Africa. But recent studies have reported the emergence of multi-drug resistant (MDR) phenotype in Salmonella tphimurium DT104, which causes infection in humans and cattle.

Note: A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals.

Wrapping up

The continuous adaptation of this bacteria to the available antibiotics creates a risk of developing antimicrobial resistance in the future. This is the reason why it is essential to study the effect of new drugs and find their potential targets in Salmonella in detail.
The strategy to target outer membrane protein A (OmpA) of Salmonella can also be used to develop novel antimicrobials for other pathogens that can effectively reduce the risk of antimicrobial resistance (AMR) in the future.

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AMR: https://www.iasgyan.in/daily-current-affairs/global-research-on-antimicrobial-resistance-gram-report

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