Context

• DBT-National Institute of Biomedical Genomics (NIBMG), Kalyani has created a database of genomic variations in oral cancer; the first of its kind in the world.
• NIBMG has made this database publicly-accessible.

About

• dbGENVOC is a browsable online database of GENomic Variants of Oral Cancer and is a free resource.
• First release of dbGENVOC contains
• ~24 million somatic and germline variants derived from whole exome sequences of 100 Indian oral cancer patients and whole genome sequences of 5 oral cancer patients from India,
• somatic variation data from 220 patient samples drawn from the USA and analyzed by TCGA-HNSCC project and
• Manually curated variation data of 118 patients from recently published peer-reviewed publications.
• Oral cancer is the most prevalent form of cancer among men in India, largely fuelled by tobacco-chewing.
• Tobacco-chewing causes changes in the genetic material of cells in the oral cavity. These changes (mutations) precipitate oral cancer.

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